Penn State Inflammatory Bowel Disease Center is on the cutting edge of diagnosis and treatments for克罗恩病和ulcerative colitis, including advanced medicines and new, investigational drugs. IBD patients who come to the Center not only receive the latest in conventional care but also have the option of enrolling in trials of new drug treatments that they otherwise would not have access to. Learn more about currentclinical trials.
克罗恩病的药物疗法
Depending on the severity of your condition, different types of drugs may be recommended to you. The main medications for Crohn's disease include:
- Aminosalicylates(5-ASAs) are anti-inflammatory drugs, which are usually used to treat mild-to-moderate disease. The standard aminosalicylate used for Crohn's disease is sulfasalazine (Azulfidine, generic).
- Corticosteroidsare used to treat moderate-to-severe disease. Common corticosteroids include prednisone (Deltasone, generic) and methylprednisone (Medrol, generic). Budesonide (Entocort) is a newer type of steroid. Because corticosteroids can have severe side effects, we use them only in the short term. We do not promote continued use of steroids as a maintenance therapy.
- Immunosuppressives，也称为免疫调节剂或免疫修饰剂，阻止了与肠炎症反应有关的免疫系统中的作用。标准免疫抑制剂包括硫唑嘌呤（Imuran，Azasan，仿制药），6-羟基托嘌呤（6-MP，Purinethol，inencic）和甲氨蝶呤（Rheumatrex，Generic）。这些药物用于长期维持疗法，并有助于减少您先前处方的类固醇的剂量。
- Biologic drugsare generally used to treat moderate-to-severe disease. They include infliximab (Remicade), adalimumab (Humira), certolizumab (Cimzia), and natalizumab (Tysabri). Infliximab, adalimumab, and certolizumab target the inflammatory immune factor known as tumor necrosis factor (TNF). They also target the immune system.
Drug Therapies for Ulcerative Colitis
Drug therapies for ulcerative colitis aim to resolve symptoms and prevent flare-ups. The main types of drugs used for treating ulcerative colitis include:
- Aminosalicylates. Mild-to-moderate ulcerative colitis is usually treated with aspirin-like medications called aminosalicylates, or 5-ASAs. These drugs are also used to treat relapses. They may be administered rectally in patients who have mild-to-moderate disease that occurs only in the last portion of the intestine. They may also be taken by mouth.
- Corticosteroids. Corticosteroids (steroids) may be added or used alone to reduce acute inflammation. Because of their significant side effects, we do not promote their frequent use. They are not intended for maintenance therapy. Steroids may be administered rectally as an alternative to an aminosalicylate if the disease is limited to the last portion of the intestine. Forms taken by mouth may treat moderate-to-severe cases. People who do not respond to less aggressive treatments may need intravenous steroids.
- Immunosuppressants是抑制免疫系统的药物。它们是单独或组合的有用的，对于对其他治疗方法不反应或维持减免的疾病都是有用的。
- Biologic drugsare designed to stimulate the immune system and interfere with specific proteins (cytokines) involved with the inflammatory response. Infliximab (Remicade) is the only biologic drug approved for ulcerative colitis. It blocks a cytokine called tumor necrosis factor (TNF).